Synonym(s): - LOGIC syndrome - Laryngeal and ocular granulation tissue in children from the Indian subcontinent syndrome - Laryngo-onycho-cutaneous syndrome - Shabbir syndrome
Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare odontologic disease - Rare respiratory disease - Rare skin disease Entire classification		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - See
Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		External references: 1 OMIM reference - See No MeSH references
More Info - Orphanet

Gene symbol	UniProt reference	OMIM reference
LAMA3	Q16787	600805

- Abnormal cry / voice / phonation disorder / nasal speech
- Abnormal fingernails
- Abnormal pigmentation of the oral mucosa / gingivae
- Abnormal toenails
- Absent / small fingernails / anonychia of hands
- Anomalies of skin, subcutaneous tissue and mucosae
- Anomalies of teeth and dentition
- Autosomal recessive inheritance
- Chronic skin infection / ulcerations / ulcers / cancrum
- Corneal clouding / opacity / vascularisation
- Death in infancy
- Enamel anomaly
- Tracheo-esophageal fistula / esophageal atresia / stenosis

- Repeat respiratory infections
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction